Current projects: Molecular BioPhysics and Nanoscience
Viscoelastic Enzyme: Different materials can be grouped according to their mechanical properties.
Solids, when subjected to a small shear force, respond with a strain proportional to the force, while liquids respond with a strain rate proportional to the force. Enzymes do both.
With this experiment, we discovered that enzymes are viscoelastic. It means the dynamical response is elastic at high frequencies and resembles a viscous flow at low frequencies. Read more.
Mechanical control of chemical reactions: Molecular level control of chemical reactions (as opposed to macroscopic thermodynamic control) is a requisite for networking many reactions together in the same volume, as in the cell. Our Lab pioneered the mechanical control of enzymes as a universal, modular control mechanism for chemical reactions.
There are approximately 104 known different enzymatic reactions; each one can in principle be thus subjected to molecular control! Read more.
Bifurcations and nonlinearity with macromolecules: Compact macromolecules such as enzymes display unusual mechanical properties. They are interesting materials.
For example, the individual molecule is a “self-healing” chunk of matter which can "fracture" and re-assemble reversibly. Read more.
The shape of clouds: The question that interests us is what aspects of the cloud can be understood simply in terms of the coherent structures in the flow field. This is a question one can ask of many turbulent systems, and the answer in this case is the shape of the cloud. Available soon.
Synthetic control of ion channels: It is a matter of considerable interest to design new modes of control for ion channels: these can then be used in neuroscience research. Our approach is that such deformable molecules can always be controlled mechanically. Thus we design artificial control mechanisms based ultimately on exerting stresses on the molecule. Read more.
Mystery project: Non-theological use in English, "a hidden or secret thing," is from late 14c. In reference to the ancient rites of Greece, Egypt, etc. it is attested from 1640s. Meaning "detective story" first recorded in English 1908. "Handicraft, trade, art" (archaic), late 14c., from Medieval Latin misterium, alteration of Latin ministerium "service, occupation, office, ministry" (see ministry ), influenced in form by Medieval Latin mysterium (see mystery (n.1)) and in sense by maistrie "mastery." Available soon.